Rong
Xu
Spatially Resolved Outflow Kinematics in Gravitationally Lensed Galaxies
Abstract profile. Full document pending author claim.
Authors:
Rong Xu, Keerthi Vasan G.C, Kim-Vy Tran
Date Created:
2025-01-01
Course Title:
Professor:
Not specified
About Paper:
Galactic outflows, driven by the energy and momentum input galaxies in the image plane using observations from the Keck from stellar evolutionary processes such as supernovae and stellar Cosmic Web Imager (KCWI), mapping outflows in multiple rest- winds, redistribute both neutral-atomic and molecular gas into frame ultraviolet ISM absorption lines with respect to the stars and the interstellar and circumgalactic medium (ISM and CGM). This nebular gas. We quantify this variation in outflow kinematics by process enriches galactic environments with metals and forms gas fitting Gaussians to the ISM absorption profile for each KCWI reservoirs that fuel star formation, ultimately shaping the growth spaxel of each lensed galaxy, measuring key outflow velocity and evolution of galaxies across cosmic time. Strong gravitational metrics such as v 50the velocity at 50% absorption in the line lensing, a phenomenon in which a massive foreground galaxy profile. Our preliminary results demonstrate significant spatial (deflector) bends the light from distant background galaxies variation across individual galaxy halos with median outflow (sources), generatingmultiplemagnifiedimagesofthebackground velocities ranging from ▯120 ▯ 29 to ▯261 ▯ 86 km/s. Future source in the plane of the deflector (image plane) enables us work will investigate the cause of these observed spatial variations to conduct detailed studies of outflows in galaxies in the early in outflow velocities. This statistical sample of lensed galaxies universe. Lensed galaxies appear brighter and more extended than with resolved outflow properties will serve as a benchmark for their unlensed counterparts, making them ideal targets for resolvedcomparison with theoretical models and cosmological simulations studies using Integral Field Spectrographs (IFS). We investigate of galaxy-driven winds, uncovering the cosmic history of baryonic thespatialvariationinoutflowpropertiesinasampleofninelensed cycling in the universe to test existing cosmological models. Lipid-drivenMechanismsofCellLineageSpecificationinOncohistoneGliomas Rebecca Xue, Pruthvi Gowda, Nika Danial Harvard College | Winthrop House | Molecular and Cellular Biology | 2028 H3K27M diffuse midline gliomas (DMGs) are lethal pediatric inhibiting tumor growth in preclinical tumor models. This project brain tumors with a median survival time of 10-18 months and aims to elucidate mechanisms underlying the pro-differentiation no curative therapies. DMGs are driven by selective alterations capacity of these lipids by identifying their protein ligands/targets. in chromatin architecture that keep H3K27M glial progenitors in a To this end, we have profiled thermal stabilization of proteins stem-like state, preventing their differentiation into glial lineages.DMG cells after treatment with these lipids using a cellular However, H3K27M progenitor cells retain some potential to thermal shift assay. Preliminary results revealed candidate lipid partially differentiate, and strategies that force differentiation binding proteins that will be functionally validated using genetic of these cells toward more mature glial-like cells blunt their gain- and loss- of function studies, as well as detailed biochemical tumorigenic potential in pre-clinical models of DMG. We have studiesinpatient-derivedandprimaryH3K27MDMGcellmodels. recently identified a class of semi-essential lipids present in serumpid-dependent mechanisms controlling lineage differentiation and diet that are necessary and sufficient for differentiation in in H3K27M DMGs may lay the foundation for diet based H3K27M glial progenitors. Importantly, diet mediated enrichment combinatorial therapies that leverage endogenous differentiation oftheselipidsinthe braintriggersthisdevelopmentalshiftin-vivo, programs to suppress tumor growth. RapidIdentificationofRadiationMedicalCountermeasuresinaHumanLung
Abstract:
Galactic outflows, driven by the energy and momentum input galaxies in the image plane using observations from the Keck from stellar evolutionary processes such as supernovae and stellar Cosmic Web Imager (KCWI), mapping outflows in multiple rest- winds, redistribute both neutral-atomic and molecular gas into frame ultraviolet ISM absorption lines with respect to the stars and the interstellar and circumgalactic medium (ISM and CGM). This nebular gas. We quantify this variation in outflow kinematics by process enriches galactic environments with metals and forms gas fitting Gaussians to the ISM absorption profile for each KCWI reservoirs that fuel star formation, ultimately shaping the growth spaxel of each lensed galaxy, measuring key outflow velocity and evolution of galaxies across cosmic time. Strong gravitational metrics such as v 50the velocity at 50% absorption in the line lensing, a phenomenon in which a massive foreground galaxy profile. Our preliminary results demonstrate significant spatial (deflector) bends the light from distant background galaxies variation across individual galaxy halos with median outflow (sources), generatingmultiplemagnifiedimagesofthebackground velocities ranging from ▯120 ▯ 29 to ▯261 ▯ 86 km/s. Future source in the plane of the deflector (image plane) enables us work will investigate the cause of these observed spatial variations to conduct detailed studies of outflows in galaxies in the early in outflow velocities. This statistical sample of lensed galaxies universe. Lensed galaxies appear brighter and more extended than with resolved outflow properties will serve as a benchmark for their unlensed counterparts, making them ideal targets for resolvedcomparison with theoretical models and cosmological simulations studies using Integral Field Spectrographs (IFS). We investigate of galaxy-driven winds, uncovering the cosmic history of baryonic thespatialvariationinoutflowpropertiesinasampleofninelensed cycling in the universe to test existing cosmological models. Lipid-drivenMechanismsofCellLineageSpecificationinOncohistoneGliomas Rebecca Xue, Pruthvi Gowda, Nika Danial Harvard College | Winthrop House | Molecular and Cellular Biology | 2028 H3K27M diffuse midline gliomas (DMGs) are lethal pediatric inhibiting tumor growth in preclinical tumor models. This project brain tumors with a median survival time of 10-18 months and aims to elucidate mechanisms underlying the pro-differentiation no curative therapies. DMGs are driven by selective alterations capacity of these lipids by identifying their protein ligands/targets. in chromatin architecture that keep H3K27M glial progenitors in a To this end, we have profiled thermal stabilization of proteins stem-like state, preventing their differentiation into glial lineages.DMG cells after treatment with these lipids using a cellular However, H3K27M progenitor cells retain some potential to thermal shift assay. Preliminary results revealed candidate lipid partially differentiate, and strategies that force differentiation binding proteins that will be functionally validated using genetic of these cells toward more mature glial-like cells blunt their gain- and loss- of function studies, as well as detailed biochemical tumorigenic potential in pre-clinical models of DMG. We have studiesinpatient-derivedandprimaryH3K27MDMGcellmodels. recently identified a class of semi-essential lipids present in serumpid-dependent mechanisms controlling lineage differentiation and diet that are necessary and sufficient for differentiation in in H3K27M DMGs may lay the foundation for diet based H3K27M glial progenitors. Importantly, diet mediated enrichment combinatorial therapies that leverage endogenous differentiation oftheselipidsinthe braintriggersthisdevelopmentalshiftin-vivo, programs to suppress tumor growth. RapidIdentificationofRadiationMedicalCountermeasuresinaHumanLung
Source:
Harvard / Julianne Wu, Jackson Weir, Fei Chen / 2025
Topics:
galaxy, outflow, lipid, h3k27m, differentiation, lensed, using, velocity, model, tumor, glial, cell
