150 Research Experience for Undergraduates External Mechanical Stimulation of the Gastrointestinal Tract

Authors:

Claire Hays, Andrea Elizabeth Biju, Shriya Srinivasan

Date Created:

2025-01-01

Course Title:

Professor:

Not specified

About Paper:

Low gastric motility contributes to numerous medical conditions large intestine and match the frequency range shown to have the and has a variety of adverse effects. Prior work has shown most effect on mechanoreceptors. Circuitry was designed for the role of gastrointestinal (GI) mechanoreceptors in controlling compactness, protection of electronics, and microcontroller-based gastric motility. By stimulating these mechanoreceptors, we frequency modulation during continuous use. A flexible resin aim to increase gastric motility. Existing devices for GI component attached to the harness maintains contact between the mechanostimulation are ingestible or implantable, presenting motors and abdomen. safety-related design limitations. This study develops a device Rats and mice remained mobile in the harness for multiple hours. for external stimulation, ideal due to being minimally invasive Using a strain gauge, the ability of the device to exert a strain and easy to use. Because mechanoreceptors can sense distension on the abdomen of murine subjects was validated. Stimulation in the gut wall, we hypothesize that external stimulation will promote gastric motility. By testing a range of frequencies, this efficacy was evaluated using a carmine dye GI transit assay in mice. The frequency which results in the largest decrease in transit external device will also elucidate the optimal vibration frequencytimecorrespondstothemosteffectivestimulationandsupportsour for stimulation hypothesis of external mechanostimulation to promote intestinal A flexible harness was designed and fitted to rodent models, motility. Duty cycle was also varied to minimize the power output emphasizing comfort and adjustable features to enable use in required to achieve stimulation. Preliminary work has shown this multiple subjects. The harness incorporates multiple eccentric device’s potential in determining suitable ranges of frequency for rotating mass (ERM) vibration motors, with the number, stimulation. positioning, and frequency of motors optimized to target the Nano-Electromechanical Actuation Device Made for Diamond Defect Applications Leonardo Herrera, Katie Barajas, Marko Loncar South Mountain Community College | Mechanical Engineering | 2027 The silicon vacancy center in diamond (SiV ) has proven to be an routing and tuning, enabling the progression of quantum node ideal platform for quantum systems due to long coherence time for efficiency and scalability. Inspired by work done in other material spin states, bright emission into the zero phonon line, and stabiliplatforms,wepresentprogresstowardatunabledirectionalcoupler in nanos▯ructures. While nanostructures enhance properties of consisting of two coupled waveguides whose distance is▯adjusted the SiV , recent work has demonstrated the ability to tune by an external voltage. This design is tailored for SiV platform SiV properties through engineering electromechanical devices in applications including photon routing via directional coupling, diamond. By introducing electromechanically actuated structures, tunable gaps for cavity coupling, and related quantum photonic we open up the possibility to develop mechanisms for photon operations.

Abstract:

Low gastric motility contributes to numerous medical conditions large intestine and match the frequency range shown to have the and has a variety of adverse effects. Prior work has shown most effect on mechanoreceptors. Circuitry was designed for the role of gastrointestinal (GI) mechanoreceptors in controlling compactness, protection of electronics, and microcontroller-based gastric motility. By stimulating these mechanoreceptors, we frequency modulation during continuous use. A flexible resin aim to increase gastric motility. Existing devices for GI component attached to the harness maintains contact between the mechanostimulation are ingestible or implantable, presenting motors and abdomen. safety-related design limitations. This study develops a device Rats and mice remained mobile in the harness for multiple hours. for external stimulation, ideal due to being minimally invasive Using a strain gauge, the ability of the device to exert a strain and easy to use. Because mechanoreceptors can sense distension on the abdomen of murine subjects was validated. Stimulation in the gut wall, we hypothesize that external stimulation will promote gastric motility. By testing a range of frequencies, this efficacy was evaluated using a carmine dye GI transit assay in mice. The frequency which results in the largest decrease in transit external device will also elucidate the optimal vibration frequencytimecorrespondstothemosteffectivestimulationandsupportsour for stimulation hypothesis of external mechanostimulation to promote intestinal A flexible harness was designed and fitted to rodent models, motility. Duty cycle was also varied to minimize the power output emphasizing comfort and adjustable features to enable use in required to achieve stimulation. Preliminary work has shown this multiple subjects. The harness incorporates multiple eccentric device’s potential in determining suitable ranges of frequency for rotating mass (ERM) vibration motors, with the number, stimulation. positioning, and frequency of motors optimized to target the Nano-Electromechanical Actuation Device Made for Diamond Defect Applications Leonardo Herrera, Katie Barajas, Marko Loncar South Mountain Community College | Mechanical Engineering | 2027 The silicon vacancy center in diamond (SiV ) has proven to be an routing and tuning, enabling the progression of quantum node ideal platform for quantum systems due to long coherence time for efficiency and scalability. Inspired by work done in other material spin states, bright emission into the zero phonon line, and stabiliplatforms,wepresentprogresstowardatunabledirectionalcoupler in nanos▯ructures. While nanostructures enhance properties of consisting of two coupled waveguides whose distance is▯adjusted the SiV , recent work has demonstrated the ability to tune by an external voltage. This design is tailored for SiV platform SiV properties through engineering electromechanical devices in applications including photon routing via directional coupling, diamond. By introducing electromechanically actuated structures, tunable gaps for cavity coupling, and related quantum photonic we open up the possibility to develop mechanisms for photon operations.

Source:

Harvard / Tae Esperanza Cooper, Michael Gee, Joanna Aizenberg, Frank Keutch / 2025

Topics:

stimulation, device, external, frequency, motility, gastric, work, mechanoreceptor, harnes, siv, mechanical, range

Co-authors:

@clairehays422 , @andreaelizabethbiju423 , @shriyasrinivasan424