Testing Circuit Models In Serotonin Induced Escape Responses

Authors:

Isaac Haber, Mariela Petkova, Florian Engert

Date Created:

2025-01-01

Course Title:

Professor:

Not specified

About Paper:

Oneimportantquestioninneuroscienceishowsensoryinformation and probability of escape. We addressed this question using is processed into motor action. We address this problem in connectomics, a method in which electron microscopy images are zebrafish by mapping the neurons and connections between takeninhighenoughresolutiontoseesynapses. Wefindthatoutof sensory receptors and motor neurons in the context of a all ~100 sensory neurons, only 11 contact the Mauthner neuron (a specific behavior where zebrafish rapidly escape when exposed specialized motor command neuron responsible for fast escapes) to serotonin. Previous studies have shown that when a larval and no other motor neurons. Instead, we identified an indirect zebrafish is injured its skin cells release serotonin which diffuses link between motor and sensory neurons through interneurons throughout the water and sends a “danger” signal to nearby fish. which form connections with motor neurons on both sides of Tosenseserotoninzebrafishutilizehaircellsonthesurfaceoftheir the fish simultaneously. We continue to quantify the patterns of body and send information to the brain via sensory neurons called connectivity, but our preliminary observations strongly suggest afferents. Here, we ask how the sensory neurons communicate that serotonin increases the “readiness” to escape. While we with motor neurons to produce escape responses. There are address a specific sensorimotor question in zebrafish, this research two possibilities: (i) a reflex, where direct communication with demonstrates more broadly how connectomics can be used to test motor neurons produces fast escape, (ii) indirect communication neural circuit models. to the motor neuron population as a whole to increase ”readiness”

Abstract:

Oneimportantquestioninneuroscienceishowsensoryinformation and probability of escape. We addressed this question using is processed into motor action. We address this problem in connectomics, a method in which electron microscopy images are zebrafish by mapping the neurons and connections between takeninhighenoughresolutiontoseesynapses. Wefindthatoutof sensory receptors and motor neurons in the context of a all ~100 sensory neurons, only 11 contact the Mauthner neuron (a specific behavior where zebrafish rapidly escape when exposed specialized motor command neuron responsible for fast escapes) to serotonin. Previous studies have shown that when a larval and no other motor neurons. Instead, we identified an indirect zebrafish is injured its skin cells release serotonin which diffuses link between motor and sensory neurons through interneurons throughout the water and sends a “danger” signal to nearby fish. which form connections with motor neurons on both sides of Tosenseserotoninzebrafishutilizehaircellsonthesurfaceoftheir the fish simultaneously. We continue to quantify the patterns of body and send information to the brain via sensory neurons called connectivity, but our preliminary observations strongly suggest afferents. Here, we ask how the sensory neurons communicate that serotonin increases the “readiness” to escape. While we with motor neurons to produce escape responses. There are address a specific sensorimotor question in zebrafish, this research two possibilities: (i) a reflex, where direct communication with demonstrates more broadly how connectomics can be used to test motor neurons produces fast escape, (ii) indirect communication neural circuit models. to the motor neuron population as a whole to increase ”readiness”

Source:

Harvard / Connectomics Internship / 2025

Topics:

neuron, motor, escape, sensory, serotonin, zebrafish, connectomic, circuit, model, response, question, addres

Co-authors:

@isaachaber436 , @marielapetkova437 , @florianengert326