The Role of Follicle-Stimulating Hormone (FSH) in Skeletal Muscle Loss Post-Menopause

Date Created:

2025-08-09

Course Title:

Professor:

Tyler McNeill and Fabrisia Ambrosio

About Paper:

Muscle loss after menopause is usually discussed through estrogen, but this project asks whether rising follicle-stimulating hormone also contributes. Using ovariectomized mice as a menopause model, the team compares untreated animals with animals receiving an FSH-blocking antibody, and also studies whether neuromuscular electrical stimulation can improve muscle quality. The practical stakes are high: if FSH helps drive post-menopausal muscle decline, clinicians may have a new target for protecting strength, mobility, and healthy aging. Source: 2025 Harvard Summer Undergraduate Research Village Abstract Book

Topics:

menopause, skeletal muscle, FSH, regenerative rehabilitation

Co-authors:

@tylermcneill102 , @fabrisiaambrosio103