Dora
Michaelides
Investigating the Role ofTMED Cargo Receptors in Brain Health and Disease
Abstract profile. Full document pending author claim.
Authors:
Dora Michaelides, Giulia Monti, Anna Greka
Date Created:
2025-01-01
Course Title:
Professor:
Not specified
About Paper:
Alzheimer’s disease (AD) is a progressive neurodegenerative imaging on brain tissue from an AD mouse model and wild- disorder affecting over 55 million people worldwide. A type controls. The goal of these experiments is to determine pathological hallmark of AD is amyloid plaques, composed of the role of TMED cargo receptors in brain health and disease amyloid-β protein, a misfolded protein, resulting from aberrant by comparing the subcellular localization of amyloid-β and trafficking and processing of amyloid precursor protein (APP). TMED markers between wild-type and AD brains. To further Recent research has shown that misfolded proteins interact with investigate the role of TMEDs in AD, we will treat animals members of the transmembrane Emp24 protein transport domain- with a TMED-targeting compound and examine AD hallmarks, containing (TMED) family of cargo receptors which regulate suchasamyloid-βaccumulation,mitochondrialproteinexpression, protein trafficking in the early secretory pathway. Despite synaptic changes, and microglial activation. This work aims to prior research showing the involvement of the TMEDs in toxic improve our understanding of protein trafficking and processing in proteinopathies, their role remains poorly understood in the braiAlzheimer’sdisease, particularlyhowTMED-mediatedtrafficking in the context of AD. As such, we plan to investigate the role ofpathways contribute to AD pathogenesis, potentially revealing TMED cargo receptors in AD by performing immunofluorescent novel therapeutic targets. Harvard-Amgen Scholars Program 7
Abstract:
Alzheimer’s disease (AD) is a progressive neurodegenerative imaging on brain tissue from an AD mouse model and wild- disorder affecting over 55 million people worldwide. A type controls. The goal of these experiments is to determine pathological hallmark of AD is amyloid plaques, composed of the role of TMED cargo receptors in brain health and disease amyloid-β protein, a misfolded protein, resulting from aberrant by comparing the subcellular localization of amyloid-β and trafficking and processing of amyloid precursor protein (APP). TMED markers between wild-type and AD brains. To further Recent research has shown that misfolded proteins interact with investigate the role of TMEDs in AD, we will treat animals members of the transmembrane Emp24 protein transport domain- with a TMED-targeting compound and examine AD hallmarks, containing (TMED) family of cargo receptors which regulate suchasamyloid-βaccumulation,mitochondrialproteinexpression, protein trafficking in the early secretory pathway. Despite synaptic changes, and microglial activation. This work aims to prior research showing the involvement of the TMEDs in toxic improve our understanding of protein trafficking and processing in proteinopathies, their role remains poorly understood in the braiAlzheimer’sdisease, particularlyhowTMED-mediatedtrafficking in the context of AD. As such, we plan to investigate the role ofpathways contribute to AD pathogenesis, potentially revealing TMED cargo receptors in AD by performing immunofluorescent novel therapeutic targets. Harvard-Amgen Scholars Program 7
Source:
Harvard / Worcester Polytechnic Institute | Neuroscience | 2026 / 2025
Topics:
tmed, protein, role, cargo, receptor, brain, amyloid, disease, trafficking, health, wild, hallmark
