Authors:

Lily Welsh

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may contribute to this sex disparity. Thus, it is important to define changes in how the brain and ovary interact that contribute to AD pathology. To investigate this relationship, we generated a mouse model of AD with impaired ovarian function. This was accomplished by crossing mice lackingTAF4B, which present with premature ovarian dysfunction, with PS19 mice, which develop tau tangles. We confirmed ovarian dysfunction along with changes in the estrus cycle in mice lacking TAF4B. We next assessed the impact of ovarian dysfunction on the ability of mice to perform cognitive tasks. Additionally, we performed immunohistological analysis of brain tissue to determine the effect of ovarian dysfunction on neuropathological hallmarks of AD that include the accumulation of tau tangles in neurons. Altogether, this study will provide insights into the role of the ovary and related molecules on the initiation and progression of AD in women. Lloyd-Sho Akai-Dennis:

Source:

Brown / SPRINT|Undergraduate Teaching and Research Awards (UTRA)

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Co-authors:

Lily Welsh