Authors:

Mously Mbacke

Date Created:

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About Paper:

role of the lung microbiota in the tumor microenvironment as both a modulator of lung immunity as well as a litmus for immune dynamics within the lung. Utilizing a novel, engineered, NSCLC line that expresses neoantigen to increase infiltration of either CD4+ and CD8+ T-cells (KP-NINJA) or CD4+, CD8+ T-cells, and B-cells (KP-HELLO), we observed that immune infiltration plays an integral role in preserving microbial diversity. Furthermore, we found that lungs containing tumors that express neoantigen, attracting tumor-infiltrating lymphocytes (TILs), had observable differences in lipopolysaccharide (LPS) expression as detected by immunofluorescent staining. The differences observed in microbial composition, as well as immunofluorescent staining, were also paired with altered infiltration of other immune subtypes, including innate cells, at experimental endpoint, indicating that TILs may orchestrate a pleiotropic response to the immune repertoire that collectively results in the preservation of the microbiota. These results are a novel finding in understanding how tumor immunity may affect organ systems holistically, and furthermore, strengthen our understanding of the multiple key players within the tumor microenvironment. Wisdom Ufondu:

Source:

Brown / SPRINT|Undergraduate Teaching and Research Awards (UTRA)

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Co-authors:

Mously Mbacke