Authors:

Congyun Liao

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About Paper:

doctors visualize changes in a patient's body and detect disease. While many radioisotopes are available for use, 64Cu has emerged as a promising candidate for early-stage imaging due to its sensitivity and relatively long half-life (t_1/2 = 12.7 h). Despite these advantages, there remain concerns regarding the stability of copper complexes in vivo, which may lead to the undesirable mistargeting of radioactive chemicals. One proposed mechanism for this instability is reduction-induced demetallation: endogenous biological reductants reduce Cu(II) to Cu(I), which results in copper dissociation. However, studies probing this hypothesis under physiologically relevant conditions remain limited. In our project, we investigated a family of macrocyclic polyaminocarboxylate-monoamides, attempting to characterize their thermodynamic and kinetic stability using electrochemical techniques. Variable-pH measurements and quantitative voltammetry modelling will build quantitative connections between chelator structure and stability, allowing for direct comparisons between in vivo stability and physiological redox stability for the first time. Electrochemical cells containing solutions of the copper complexes were prepared under varying pH conditions and analyzed using cyclic voltammetry, a technique for studying redox reaction kinetics. According to present data, many variables are contributing to the apparent copper loss from chelators, including pH, chelator structure, and the rate at which potential is applied. These results uncover the complexity of the reduction-induced demetallation hypothesis, and we hope to collect more in-depth data that captures a broader picture through computational simulations and other electrochemical techniques, such as chronoamperometry. Mike Woodilla:

Source:

Brown / SPRINT|Undergraduate Teaching and Research Awards (UTRA)

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Co-authors:

Congyun Liao