Authors:

Sara Jaradat

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About Paper:

Preventive medication treatments are effective in reducing the risk of breast cancer, but the uptake of such medication treatments for primary breast cancer prevention remains suboptimal, often below 5%. This systematic review evaluated the effectiveness of various interventions designed to improve the uptake of preventive medications for breast cancer high risk population. We systematically searched MEDLINE, Web of Science, and PsycINFO databases for clinical trials and observational studies that evaluated the impact of interventions on various preventive medication treatment uptake among populations with high risk for breast cancer from inception to October 27, 2024. Of 863 publications identified, 734 abstracts were screened after removing duplicates, and 11 full-text articles that met the inclusion criteria were included in the review. Three studies (27%) evaluated the web-based Guide to Decide (GtD) decision aid intervention which significantly empowered the participants to make informed decisions by increasing their understanding of medications benefits and risks. Two studies (18%) found that the RealRisk decision aid intervention increased knowledge and decision quality regarding breast cancer risks and chemoprevention. Personalized interventions such as decision support systems (DSS) and personalized polygenic risk scores (PRS) significantly improved knowledge, decision satisfaction, and activated clinical discussions about chemoprevention. Only PRS increased uptake of endocrine therapy in high-risk women. Other interventions, including tamoxifen education sessions did not substantially incline participants to consider tamoxifen, possibly due to adverse effects concerns. Protection Motivation Theory (PMT) tools modestly increased intentions for preventive medications. Interventions aiming to improve the uptake of preventive medication treatments for breast cancer consistently improved knowledge and decision-making but resulted in low uptake of treatments.

Source:

Auburn University / Harrison College of Pharmacy / 2025

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Co-authors:

Sara Jaradat