Psychedelics are emerging as promising therapeutics for multiple mental health disorders. However, most of the current research on the underlying neurobiological mechanisms of psychedelics has been concentrated on rodents and is insuPicient in illustrating how psychedelics aPect sensory circuits as a whole system. The larval zebrafish is an ideal model organism as it provides optical access to the entire brain at a single-cell resolution. Their transparency allows for non-invasive, in vivo imaging, and provides an exceptional opportunity to visualize neural dynamics and circuitry in the organism. Therefore, using larval zebrafish, we investigated the sensorimotor behaviors and their underlying neural circuitry with acute exposure to the psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI). Using high-resolution multi-camera array microscope and custom-built behavior rigs, we recorded zebrafish responses to a series of locomotor, photomotor, and optomotor behaviors, as well as responses to light, dark, and vibration startles before and after exposure to DOI or a vehicle control. Fish in the DOI condition exhibited a decrease in locomotor activity in a dose-dependent manner. However, under dark stimuli (i.e., dark epoch and dark flash), this motor response had an inverted "U-shaped" dose-ePect relationship, whereas no diPerence was observed in light conditions or vibration startles. Interestingly, when fish were shown moving gratings to investigate their optomotor response behavior, the locomotor activity did not change throughout the experiment. Instead, they performed stronger turns in response to left and right visual gratings. Finally, we performed volumetric two-photon imaging in brain regions involved in sensorimotor transformations, such as the pretectum and the hindbrain, to uncover the specific neural circuits that DOI is activating or inhibiting. Future work will include determining changes in functional connectivity before and after exposure to DOI using a recurrent neural network model. Our findings demonstrate stimulatory and inhibitory functions of DOI that are concentration- and environment-dependent. These findings can propel the identification of neural circuits aPected by exposure to psychedelics and understanding how psychedelics alter sensory processing. Birth weight across Daasanach communities in Northern Kenya and the eOect of multiparity

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