Mayah
Ding
The field of quantum information and quantum computing has recently experienced a surge in interest due to experimental progress towards the anticipated usefulness of quantum computers to accomplish tasks that classical computers are unable to solve in reasonable time. The current era of quantum computing has been described as the Noisy-Intermediate Scale Quantum Era (NISQ). In other words, quantum devices are currently extremely susceptible to "noise" or error processes that destroy quantum information and reduce advantages of quantum computation over classical computation. Such advantages rely upon an important quantum resource known as entanglement. In general, noise decreases the amount of entanglement in a qubit system. Therefore, this study will examine the effect of noise on entanglement properties in various dimensional qubit systems, using a specific measure known as Negativity and its spectrum. In this study, we will combine numerical and analytic methods to derive expressions characterizing the amount of entanglement left in a qubit system under the effects of a variety of noise channels. For entanglement in many-body contexts, we will focus on even-number qubit systems with bipartite divisions. Synthesis of 15N2-diazirine probes for in vivo HP-MR imaging of human biological pathways
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Authors:
Mayah Ding
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Amino acids play critical roles in tumorigenesis, serving as nutrients for biosynthesis of macromolecules, signaling molecules, and supplementation of the Krebs cycle. Thus, visualizing the metabolism of various amino acids in vivo is crucial to better understanding cancer cell metabolism, cancer screening, and identifying possible targets for treatment. Existing probes for amino acid metabolism rely on different imaging techniques including PET, SPECT, fluorescence, MSI, and MRS, which lack sensitivity or stability for practical use. This work addresses these shortcomings through synthesizing novel 15N2- diazirine tagged amino acid probes, with a focus on glutamine and methionine. These probes can be hyperpolarized using dissolution dynamic nuclear polarization (d-DNP), providing a highly sensitive, non-invasive approach to visualizing metabolites in vivo over longer periods of time. Successful synthesis of these probes will provide promising new strategies for better cancer imaging, expanding the imaging toolbox for clinical research.
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Duke University / 2025
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Mayah Ding