Authors:

Isabelle Gerzenshtein

Date Created:

Not specified

Course Title:

Professor:

Not specified

About Paper:

Efficient and reliable assessment of altered or impeded flow of blood throughout the body, known as assessment of blood pooling in areas with a lack of blood flow, is essential in the diagnosis of patients across a variety of conditions. Current imaging modalities used to visualize accumulation of blood at places of injury or in disease (e.g., haemorrhagic cysts) include ultrasound, positron emission tomography (PET) scans, and magnetic resonance imaging (MRI). Limitations such as limited imaging depth and long scan times continue to motivate development of novel imaging modalities.1, 2 Magnetic particle imaging (MPI) is a promising tracer-based imaging modality that detects linearly quantitative signal of superparamagnetic iron oxide nanoparticles (SPIONs) due to the opposing magnetic fields generated by the instrument.2 MPI is well-suited to overcome constraints of other imaging techniques by allowing for high temporal resolution, nanoscale spatial resolution, and minimal tissue background signal. In this presentation, we summarize the current state of MPI as it relates to blood pool imaging for cardiovascular applications, highlighting recent developments in the field of MPI tracer optimization. We provide perspective on areas for future research where tracking internal bleeding or lack of blood flow will improve patient diagnosis. References: 1. Han X, Li Y, Liu W, Chen X, Song Z, Wang X, Deng Y, Tang X, Jiang Z. The Applications of Magnetic Particle Imaging: From Cell to Body. Diagnostics (Basel). 2020;10(10). Epub 20201009. doi: 10.3390/diagnostics10100800. PubMed PMID: 33050139; PMCID: PMC7600969. 2. Panagiotopoulos N, Duschka RL, Ahlborg M, Bringout G, Debbeler C, Graeser M, Kaethner C, Lüdtke-Buzug K, Medimagh H, Stelzner J, Buzug TM, Barkhausen J, Vogt FM, Haegele J. Magnetic particle imaging: current developments and future directions. International Journal of Nanomedicine. 2015;10(null):3097-114. Applications of magnetic nanoparticles and

Source:

University of Florida / Isabelle Gerzenshtein, Marisa O. Pacheco, Carlos Rinaldi- / 2023

Topics:

No topics listed

Co-authors:

Isabelle Gerzenshtein