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Cancer is a major medical concern in the Hispanic/Latina(o) community in the United States (US), and approximately 30% of Hispanic/Latina(o) persons in the US will be diagnosed with cancer durin g their lifetime (American Cancer Society, 2015). Acute cancer and cancer treatment have be en associated with cognitive decrements. However, the long-term cognitive effects of cancer am ong Hispanic/Latina(o) adults remain under-investigated. Our study addresses gap by investigating the cognitive, clinical, and contextual-level characteristics of Hispanic/Latina(o) persons with and wi thout cancer history. Hispanic/Latino(a) adults (N=1095) enrolled in the HABS-HD study ((Mage = 66.02, SD = 5.33); (Meducation = 10.03, SD = 5.05; 70% female; 92% White)) with cancer history (n=101) were compared to propensity-matched sample (matched by age and sex) of Hispanic/Latino(a ) adults ((Mage = 65.89, SD = 5.99); (Meducation = 10.00, SD = 5.54; 70% female; 90% White) ) without cancer history. History of vascular risk factors, renal and pulmonary insufficiencies, p sychiatric conditions, global cognition, learning and memory, executive functioning, processing speed, and language were assessed. Area deprivation index was calculated. Analyses of variance c alculated to assess group differences. Hispanic/Latina(o) adults with cancer history did not diff er from their counterparts in global cognition, verbally mediated memory, language, or executiv e functioning. Cancer history predicted differences in processing speed tests (Symbol Digit Modality= F(4,198)=5.77, p=0.003, Cohen's d=0.2). Regarding clinical characteristics, Hispani c/Latina(o) with cancer history differed from their counterparts in cardiovascular comorbidities (F(4,198)= 7.33, p=0.007), not on medical comorbidities or contextual factors. Hispanic/Latina( o) immigrants with cancer history exhibited subtle weaknesses in processing speed that occurred i n the context of an otherwise intact cognitive profile. Implications and future research directions will be discussed.

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University of Florida / Longoni, A.,Santos, L.G., Garriaga, S., Davenport, M., & Arias. F / 2024

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Longoni Author