Authors:

Auveen Hajarizadeh

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Techniques for Bone Healing Co-Author(s): Kylie Williams, Angela Lin, Genevieve Romanowicz, Robert Guldberg The use of noninvasive imaging allows researchers to evaluate the structure of various tissues and organs in animal models, both qualitatively and quantitatively. Traditional radiography for small animals can include microCT scans that produce hundreds of 2D slices and show internal structures at any depth, which is paramount for the field of orthopedics. The Scanco Medical vivaCT 80 is a microCT scanner that produces high-resolution images of internal animal structures, with proprietary software capable of quantifying 3D parameters. Object Research Systems Dragonfly is a 3D imaging software that can use microCT data to create detailed 3D models, which can be viewed from any angle. These manipulatable 3D models provide a thorough qualitative understanding of an animal's internal structures. The Scanco and Dragonfly softwares have allowed us to assess bone healing in different in vivo animal studies involving exercise-based rehabilitation and injectable therapeutics. We found that the Scanco software was most effective for producing quantitative measurements 158 UNIVERSITY OF OREGON • 2023 UNDERGRADUATE RESEARCH SYMPOSIUM of various parameters-such as bone volume and bone mineral density-while Dragonfly was most effective for producing high-quality, visually appealing 3D models for qualitative analysis of microCT data sets. This knowledge can help aid preclinical data collection, analysis, and image display strategies when investigating bone healing after the use of therapeutics or rehabilitation.

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University of Oregon / 2023

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Co-authors:

Auveen Hajarizadeh