Authors:

Nicholas Herschel Burris

Date Created:

Not specified

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About Paper:

The nervous system is composed of nerve fibers that transmit information through pulse code modulated bioelectric solitons called action potentials (AP) that travel along the nerve fiber. Being a soliton, APs are robust and stable, making them difficult to block using electrical blocking stimuli, although they can be chemically blocked using Na+ channel blockers such as lidocaine. A recently discovered electrical method to block is using sinusoidal low frequency alternating current (LFAC) stimulation. LFAC produces low threshold electrical nerve conduction block (NCB), but full time NCB (ftNCB) is not possible through a single bipolar cuff electrode. FtNCB requires at least two-channels of phased LFAC stimulation. This research aims to implement ftNCB using two-channels LFAC. Software to control the stimulation parameters to achieve ftNCB was implemented to automatically interrogate different phase delays and amplitudes. In-vivo experiments on earthworms using single channel LFAC show that block was conducted to be followed by planned two-channel experiments. Analysis of the data involved digital signal processing using several MATLAB scripts to visualize effects of LFAC. The preliminary results revealed that the updated software can modulate sinusoidal phase and amplitude to interrogate and determine whether ftNCB can be achieved using two-channel LFAC. Keywords: Nerve Block; Conduction Block; Electrical Stimulation; Low Frequency Alternating Current Block

Source:

Purdue University / 2024

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Co-authors:

Nicholas Herschel Burris