Authors:

Jennifer Lee

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About Paper:

The human vascular system exhibits significant diversity and heterogeneity of lumen shapes and sizes. Within the vasculature, blood vessels display a range of diameters as well as variations in vessel architecture, for example, aneurysms, stenosis, tortuosity, branching etc. The complex architectures of these vessels result in altered hemodynamics and subsequently endothelial cell phenotype, which cannot be recapitulated with uniform blood vessels. Hence it is important to incorporate the spatial variations that exist in vivo and fabricate physiologically relevant, complex embedded lumen. Gravitational Lumen Patterning (GLP) is a surface tension and pressure driven biofabrication technique that has been employed in vascular organ-chip research to create simple, uniform cylindrical vessels that are embedded in collagen. The hypothesis was that the shape of the patterned collagen lumen is dictated by the shape and size of the external microfluidic channel. It was observed that using GLP in different external microfluidic channels, it is possible to generate vessels with aneurisms, stenosis, branches, tortuosity, and varying widths. This study demonstrates a simple yet powerful application of the GLP biofabrication technique to create vessels with spatially complex architectures. These vessels closely mimic the structural variations that are observed in vivo and can eventually be used to investigate vascular complications like aortic aneurysm, atherosclerosis, and carotid artery etc., where vessel architecture plays a crucial role in disease onset and progression. Poster #16 Engineering Synthetic Protein Binders to Hepatitis C Virus Core Antigen Sam Vrana

Source:

Texas A&M University / 2024

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Co-authors:

Jennifer Lee