Authors:

Mary Rocchio

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About Paper:

Degradable polymer stents are becoming more widely used as they decrease the risk for in-stent restenosis and stent thrombosis. These degradable stents reduce chronic inflammation and allow endothelial regrowth at the implantation site. However, this is a novel approach for stent design, so there is limited research on how best to image degradable stents. These devices are difficult to image because of their similar density to soft tissue, producing low contrast in the images and causing high error when calculating percent stent degradation. This study aims to develop an imaging phantom composed of plastic filament and synthetic tissue that mimics degradable stents implanted in cardiac tissue for micro-CT analysis. PLA, ABS, and ASA filaments were used to model a 3D printed stent in micro-CT scans. The densities were then compared to soft tissue density of pig heart tissue. Synthetic tissues of gelatin, silicone, and polyvinyl alcohol (PVA) were analyzed using x-ray analysis and compared to the pig heart tissue. The filament and synthetic tissue with the most similar density to that of pig will be selected in order to create the smallest difference between the two densities, producing the issue of minimal device-tissue contrast. This will imitate the initial problem of low contrast found while imaging the stents in vitro. The actual and measured volumes of the stent are to be measured to determine how the phantom tissue performed. The results are expected to show the best synthetic tissue to be used to measure how devices degrade over time. With the development of this phantom tissue, medical device designers will be able to more accurately determine how their device degrades post-implantation in in vitro studies with micro-CT imaging. Poster #4 Sex-Specific Mechanisms of Active Avoidance Claire J. Pitre

Source:

Texas A&M University / 2025

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Co-authors:

Mary Rocchio