Ellen
Feuss
Sponsor: Giovanni Peri, Ph.D. Economics I study how a students' choice of college major is correlated with the industrial composition of the area where they grew up. College major choice has lasting future economic implications; I examine whether students living in an area known for or influenced by certain industries have a greater likelihood of picking a college major related to those industries. I use Economic Census data to determine local industrial employment by sector and American Community Survey data to link degree fields to industrial groupings, serving as an intermediate step to relate industrial composition to college majors. By considering how the employment of local industries predicts what fields students choose to major in, combined with the link between degrees and majors, this study reveals what effects local industries may have on the direction students seek for their careers, with implications having the ability to affect where industries decide to locate and families decide to live. Synthesis and Applications of F5SCH2 - Transfer Reagents
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Authors:
Ellen Feuss
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Fluorinated groups like the trifluoromethyl (-CF3) group have been often employed in pharmaceuticals due to their ability to modulate properties such as solubility, lipophilicity, conformation, pKa, metabolic stability, and cellular permeability. Another fluorinated group known as the pentafluorosulfanyl (SF5) group, nicknamed the "super-CF3 group," can enhance physicochemical properties of compounds relative to CF3 derivatives, yet SF5 does not appear as often as CF3 in the literature. Compared to the CF3 group, SF5 is a stronger electron-withdrawing group, larger in size/volume, more lipophilic, and more chemically stable. However, the SF5 group presents a far greater synthetic challenge than installing a CF3 group. Pentafluorosulfanyl chloride (SF5Cl) - a key source of SF5 radicals - is one of the few known SF5-transfer reagents that can install this group on organic molecules. All known pentafluorosulfanylating reagents, such as SF5Cl, are difficult to make and handle. Synthesis usually involves hazardous materials and/or specialized apparatuses. But, based on recent work in our laboratory and by others, SF5Cl is now more accessible and easier to work with. Thus, we can envision the synthesis of new SF5-containing compounds, including new reagents. This project details the first steps towards making never-before-synthesized benzylic-SF5 compounds via the design of F5SCH2-transfer reagents. Design and Test Plan of a High-Altitude Return- to-Site Vehicle Liliana Figueroa
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UC Davis / Chemistry / 2023
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Ellen Feuss