Anna
Kolesov
Sponsor: Stephen Robinson, Ph.D. Mechanical & Aerospace Engr One of the few methods of simulating spacecraft dynamics on Earth is on an air bearing table. On an air bearing table, an air bearing creates a small cushion of air between a model spacecraft and the table, enabling low-friction planar motion and simulating spacecraft dynamics. This provides 3 degrees-of- freedom: 2 translational and 1 rotational. The Human, Robotics, Vehicles Integration and Performance Laboratory (HRVIP) aims to test attitude determination systems using this method. However, attitude testing on an air bearing requires a highly flat and smooth surface, ensuring gravitational effects do not interfere with the CubeSat's dynamics. The glass surface used for previous experiments encountered many problems maintaining a flat surface. We researched two alternative materials that would allow for more accurate measurements, while meeting specified flatness and roughness requirements. While we found that precision epoxy could form a flatter surface, grade B granite would be a more cost-effective solution while still meeting our flatness and roughness requirements. The development of this in- house testing environment provides an accessible and cost- effective method for performing CubeSat research. Furthermore, our trade study analysis is useful for other universities and institutions that need to conduct similar spacecraft research. Synthesis of Raman-active Core-Shell Nanoparticles for Early Diagnosis of Ovarian Cancer
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Anna Kolesov
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Ovarian cancer diagnosed at a late stage has a 31% 5-year survival rate, while this rate for an early stage diagnosis is 93%. Therefore, there is a clear clinical need for an earlier and non- invasive ovarian cancer diagnostic technology. Our project aims to create silica-coated gold nanoparticles that will detect cancer- associated-extracellular vesicles (EVs) in a patient sample using a technique known as surface enhanced Raman spectroscopy (SERS). The gold core of the nanoparticle provides plasmonic enhancement, akin to shining a bright light on the cancer biomarkers. A self-assembled monolayer of a Raman-active tag surrounds the core to act as a unique label for each nanoparticle type. A silica shell is added to cap the Raman-tag to the nanoparticle, providing long term particle stability and an adhesive surface for EV targeting agents. Preliminary results show that an aqueous based process is ineffective in creating a consistent silica shell, while an alcohol-based, modified Stöber process can be used to create a gold core nanoparticle with a Raman-active tag and silica shell. The Role of Dynein in Nuclear Positioning in Diakinesis Spermatocytes Siri Konanoor
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UC Davis / Biomedical Engineering / 2023
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Anna Kolesov