Authors:

Taylor Tran

Date Created:

Not specified

Course Title:

Professor:

Not specified

About Paper:

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder caused by a combination of genetic and environmental factors. Our lab recently discovered NHIP (neuronal hypoxia inducible, placenta), a novel gene that encodes a long non- coding RNA and a nuclear micropeptide that is expressed at lower levels in ASD brains compared to neurotypical brains. NHIP appears to have arisen recently in the primate lineage with the expansion of brain size and neuronal activity. We hypothesize that NHIP acts as a protective factor to counter oxidative stress from elevated size and neural activity. To test this hypothesis, we used the LUHMES (Lund human mesencephalic) cell line, which can be maintained as a progenitor or differentiated into neuronal cells. We treated wild-type LUHMES neurons with cobalt chloride to mimic hypoxic conditions and then added NHIP to see whether exogenous NHIP would protect against oxidative stress, as measured by reduced oxygen species (ROS) levels. Our preliminary results suggest that adding exogenous NHIP to undifferentiated WT cells, which do not express high levels of NHIP, results in a decrease in ROS levels. Fully characterizing the function of NHIP and its role in protecting against oxidative stress will contribute to potential treatments for neurodevelopmental disorders including ASD. Aerodynamics and Acoustics Validation of Parallel Blade Vortex Interactions Huy Tran

Source:

UC Davis / MED: Medical Microbiology & Imm / 2023

Topics:

No topics listed

Co-authors:

Taylor Tran