Adyasha
Padhi
Sponsor: Christina Pasparakis, Ph.D. Environmental Toxicology Thirty-two locally caught brown rockfish were given to us by the New Sea Angler in the Bodega Head region. Our study on brown rockfish (Sebastes auriculatus) delved into aspects such as size variation and the relationship between iris diameter, the cephalic, and fork length. We compared the iris diameter to the cephalic and fork length to see if there was any correlation between the two. Additionally, comparing the cephalic length in respect to brain size. As older brown rockfish tend to live deeper in the ocean, we speculated that their iris diameter should be bigger due to needing to absorb more light. Being able to absorb more light is important for fish so they can see predators as well as their food source. Due to the reliance on light absorption it's only rational to think the eyes diameter should be bigger in relation with the overall size of the fish. These investigations contribute to understanding rockfish biology and provide valuable insights that can be further explored. Effect of Diclofenac on Cardiomyocyte Cells
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Adyasha Padhi
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Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, are commonly used to manage pain, decrease inflammation & fevers, and prevent blood clots. NSAIDs have also been linked with increased risk of gastrointestinal bleeding, myocardial infarction, and stroke. Diclofenac is an NSAID used around the world associated with the highest risk of stroke & heart attacks in clinical studies and recently became available over-the-counter in a topical form in the United States. However, the mechanisms of damage by diclofenac to cardiomyocyte cells are not well understood. The goal of my investigation is to determine if physiologically relevant doses of diclofenac increase oxidative stress and cause cardiomyocyte cell damage by conducting cell culture experiments using C2C12 mouse myoblast cells. These experiments include mitochondrial membrane potential experiments, cell survival assays, western blotting, superoxide ion detection, and proteasome biochemical assays. Preliminary results show that there were significant differences in mitochondrial membrane potential assays between control & diclofenac treatment demonstrating that diclofenac-treated cells were more likely to experience mitochondrial dysfunction. Mitochondrial membrane health is associated with oxidative stress and damage, which is supported by increased levels of reactive oxygen species in diclofenac-treated cells, and this damage is associated with higher risks of stroke & heart attack. UC Davis 35 th Annual Undergraduate Research, Scholarship and Creative Activities Conference 183 Sex-specific Regulation of Meiotic Crossover Numbers in C. elegans Pranav Padture
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UC Davis / MED: Physiology & Membrane Biol / 2024
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Adyasha Padhi