Authors:

Aysia Saeturn

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About Paper:

Biological disparities between males and females, along with age- specific susceptibilities, significantly affect how lungs respond to toxic substances. Naphthalene (NA), commonly found in wildfire smoke and vehicle emissions, poses a risk to respiratory health. Previous studies have shown increased toxicity in lung epithelial club cells of the conducting airways following NA exposure in adult mice. These cells produce club cell secretory protein (CCSP), which defends against oxidative stress. Ergothioneine (ET), a dietary antioxidant, was investigated as a potential protective pre-treatment. This study aimed to investigate whether ET could mitigate NA-induced club cell toxicity, focusing on juvenile female mice. Female mice (N=3/group) received oral ET (70 mg/kg) or saline control (SA/CO) for five days. Two experimental groups (ET/NA; SA/NA) were also given the same treatments and then all mice were injected with 150 mg/kg NA intraperitoneally, and lung tissues were examined after 24 hours. Histopathology and unbiased stereology were used to quantify epithelial changes. Preliminary findings suggest that the SA/NA group showed increased vacuolated club cells, while the ET/NA group exhibited intact, healthy cells. This implies that ET can alleviate NA-induced toxicity in the proximal airways of juvenile female mice.  Photoreceptor and RPE Degeneration in an Optogenetic Mouse Model of Geographic Atrophy Youcef Sahraoui

Source:

UC Davis / VM: Anat Physio & Cell Biology / 2024

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Co-authors:

Aysia Saeturn