Bayleigh
Baldwin
Sponsor: David Liem, M.D.,Ph.D. MED: Int Med Cardiology (davis) Heart failure with preserved ejection fraction (HFpEF) is an incurable and heterogeneous disease, and patients comprise nearly 50% of heart failure (HF) patients. With limited therapies to reduce mortality rates for HFpEF, developing treatments is indispensable. Currently, FDA-approved drugs offer novel therapeutic targets for HFpEF. Understanding the shared mechanisms between comorbidities like obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD) can shed light on the largely unknown pathophysiology of HFpEF. In particular, Resmetirom is a newly approved drug to treat nonalcoholic steatohepatitis (NASH), a subtype of NAFLD. Sodium-Glucose Cotransporter 2 (SGLT2) inhibitors, originally intended to treat diabetes and kidney disease, have been approved to treat NAFLD and have shown improvement in HFpEF patients due to its ability to improve cardiovascular outcomes and liver inflammation. We hypothesize that Resmetirom can be repurposed for HFpEF by acting as a Thyroid Hormone Receptor Beta (THR-β) agonist. To validate this hypothesis, a text mining algorithm has been used to filter manuscripts based on queries of SGLT2 inhibitors, HFpEF, NAFLD, and Resmetirom. Parsing for heart-related proteins within these texts can reveal biomarkers for future treatment options while also elucidating the interdependence between these diseases. The Social Meaning of "Country Talk" in California's Napa Valley
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Authors:
Bayleigh Baldwin
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What does it mean to be "California Country" and what role does gender play in constructing authentic "Countryness"? California's Napa Valley is located north of metropolitan San Francisco and is known worldwide for its wine industry. The goal of this study is to see if Napans identify with a Country persona and simultaneously employ features of Country Talk to create a uniquely Napa identity. Country Talk has been defined as a "national register… composed of indexical relations between American imaginings of rural practices and personae and nonstandard varieties of United States English." By completing narration tasks and sociolinguistic interviews with nine longtime Napa residents over age 55, the researcher found that all participants used both the formal /-ING/ variant and informal /-IN/ variant in progressive verb forms. No significant differences were found in /-IN/ usage between the five female and four male participants. Further work is needed to analyze the extent of the PIN/PEN merger in Country-identified Napa residents following the merger's analysis in other California Country papers. ReFill: Bringing Outdated Water Fountains into Modernity Devin Bangayan
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UC Davis / Linguistics / 2025
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Co-authors:
Bayleigh Baldwin