Marc
Gorge

Papers

Sponsor: Elisa Barbour, Ph.D. Inst Of Transportation Studies The State of California is facing simultaneous challenges in addressing climate change and a housing shortage. Transit Oriented Development (TOD) and other land-use and transportation integrative solutions provide housing that reduces the need to drive and thus greenhouse gas emissions. California has implemented several policies and programs, including Affordable Housing and Sustainable Communities, Regional Early Action Planning (REAP), Enhanced Infrastructure Finance Districts, and density bonus laws that can support land use and transportation integration. This project compared these four programs to understand how they differ in purpose, character, and scope, and to assess implications of these differences for the advancement of TOD. The research was conducted in three primary phases:  background analysis of guidelines for these programs; interviews with staff members from Metropolitan Planning Organizations, who oversee the REAP program, and with planners from the state's six "central cities" (San Francisco, San Jose, Oakland, Los Angeles, San Diego, and Sacramento); and an analysis of results from a survey of local planning directors on transportation and land use connective programs. Initial results suggest that primary factors affecting land use transportation connection outcomes are the level of government programming and administering the program, allowed uses of funding, and policy objectives. In a Rat Model of Chronic Kidney Disease, Fibrosis Develops in the Kidney but not in Skeletal Muscle

Sponsor: Elisa Barbour, Ph.D. Inst Of Transportation Studies The State of California is facing simultaneous challenges in addressing climate change and a housing shortage. Transit Oriented Development (TOD) and other land-use and transportation integrative solutions provide housing that reduces the need to drive and thus greenhouse gas emissions. California has implemented several policies and programs, including Affordable Housing and Sustainable Communities, Regional Early Action Planning (REAP), Enhanced Infrastructure Finance Districts, and density bonus laws that can support land use and transportation integration. This project compared these four programs to understand how they differ in purpose, character, and scope, and to assess implications of these differences for the advancement of TOD. The research was conducted in three primary phases:  background analysis of guidelines for these programs; interviews with staff members from Metropolitan Planning Organizations, who oversee the REAP program, and with planners from the state's six "central cities" (San Francisco, San Jose, Oakland, Los Angeles, San Diego, and Sacramento); and an analysis of results from a survey of local planning directors on transportation and land use connective programs. Initial results suggest that primary factors affecting land use transportation connection outcomes are the level of government programming and administering the program, allowed uses of funding, and policy objectives. In a Rat Model of Chronic Kidney Disease, Fibrosis Develops in the Kidney but not in Skeletal Muscle

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Marc Gorge

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Chronic kidney disease (CKD) is characterized by the gradual loss of the kidney's ability to adequately filter blood. Another key characteristic of CKD is fibrosis, defined as excessive accumulation of extracellular matrix proteins (e.g. collagen), which occurs in the kidney, heart, and lungs. While the effect on these organs is well-documented, the effect on skeletal muscle remains understudied. Here we asked if a rat model of CKD accurately mimics CKD-related muscle fibrosis observed in humans. Given CKD's association with muscle loss and decreased mobility, this would provide an important platform for future research. Thirty- two rats (50% female, age=8wk) were randomly assigned to a control (CON) or a CKD-inducing 0.25% adenine diet (AD-CKD) for 8wk. Extensor digitorum longus (EDL) and soleus (Sol) muscles, and kidneys were collected and collagen content was measured using a hydroxyproline assay. A two-way ANOVA identified a main effect of AD-CKD on collagen content in the kidney (5.1±0.66% CKD vs. 1.5±0.43% CON, p<0.0001, N=8/group) but no effect on Sol or EDL (p>0.4815). No sex or interaction effects were identified. These results suggest that fibrosis of the kidney occurs without concomitant muscle fibrosis in AD-CKD. UC Davis 36 th Annual Undergraduate Research, Scholarship and Creative Activities Conference 119 The New York Times Representation of Jordan in the 1960s Maximillian Gouvalaris

Source:

UC Davis / MED: Physiology & Membrane Biol / 2025

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Marc Gorge