Authors:

Anita Kim

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About Paper:

This study examines immune cell infiltration into the olfactory bulb (OB) of mice following nasal administration of inflammatory agents, focusing on the potential impact of SARS-CoV-2 infection. Although the OB is typically protected by the blood-brain barrier, external contaminants from the olfactory epithelium have been shown to disrupt brain function, as observed in COVID-19 patients with neurological manifestations. The aim of this research is to assess the types of immune cells present in the OB following SARS-CoV-2 infection. Understanding immune cell dynamics in the OB is critical for understanding how peripheral inflammation affects the brain. Immunostaining was performed on OB tissue from mice treated with lipopolysaccharide (LPS), polyinosinic- polycytidylic acid (poly-IC), or phosphate-buffered saline (PBS) as a control. Additionally, RNA scope was performed on OB tissue from SARS-CoV-2-infected mice and PBS-treated controls. Preliminary results show the presence of T cells in LPS-treated mice and monocytes/macrophages in both LPS- and poly-IC- treated mice, though these cells were rare. These findings suggest that immune cell infiltration in the OB could serve as a marker for brain inflammation. Future work will further explore the role of SARS-CoV-2 in triggering immune responses in the brain, with implications for understanding the neurological consequences of the virus. Inactivation of Common Foodborne Pathogens in Collard Green Juice Using Pulsed Light Treatment Elise Kim

Source:

UC Davis / MED: Cell Biology & Human Anat / 2025

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Co-authors:

Anita Kim