William
Stoehr
Sponsor: Brie Tripp, Ph.D. Neuro Physio & Behavior Public health efforts to reduce tuberculosis (TB) transmission have primarily focused on general high-risk populations, yet incarcerated populations have remained largely overlooked. Consequently, these efforts have failed to address key structural inequities-such as overcrowding, inadequate healthcare, and privatized prison medical systems-that contribute to disproportionately high TB rates in correctional facilities. To increase awareness among undergraduate pre-health students about the intersection of TB pathophysiology and systemic healthcare injustices within prisons, we have developed a case study that explores immunology through the lens of health disparities in incarcerated populations. The case study examines the physiological mechanisms of TB infection, the role of institutional policies in perpetuating disparities, and the importance of advocacy in challenging systemic injustices that contribute to inadequate healthcare for incarcerated individuals. We will implement this case study in an upper-division physiology course to engage students in critical discussions on TB disparities, systemic healthcare injustices, and the role of advocacy in addressing health inequities within incarcerated populations. We hypothesize that engaging with this case study will encourage pre-health students to critically analyze the structural factors driving health disparities in prisons and inspire them to advocate for more equitable healthcare policies. Tubulin Subtype Expression Patterns in the Embryonic Cornea
Abstract profile. Full document pending author claim.
Authors:
William Stoehr
Date Created:
Not specified
Course Title:
Professor:
Not specified
About Paper:
The cornea is the transparent outer layer of the eye that maintains clear vision. It is partially formed from embryonic neural crest cells, a group of migratory, multipotent cells that undergo dynamic changes in cell adhesion and cytoskeletal structure. One major element of the cytoskeleton are microtubules, which are polymers of alpha-beta tubulin heterodimers. Alpha- and beta-tubulins have many isotypes, but their cell type-specific expression remains largely unknown. Prior work in neural crest cells showed that precise combinations of tubulin subunits regulate cell function, and we hypothesize that specific alpha- and beta-tubulin subunits regulate corneal development. The aim of this project is to characterize the longitudinal spatiotemporal expression of tubulin isotypes in the developing cornea. Chick corneas were isolated from 3 to 16 days of incubation and immunohistochemistry was performed using antibodies against TUBA1A, TUBA1B, TUBA4A, TUBB2B, and TUBB3. High-resolution fluorescence microscopy was used to visualize tubulin localization. In concert, we analyzed open-source single-cell transcriptomics from a human fetal corneal dataset. Our results show a differential expression of tubulin isotypes across cell types and developmental stages, which was consistent with the human transcriptomic data. We propose that differential tubulin expression may be an indicator of cell function and morphology. Designing a Digital Intervention to Promote Social Belonging Among Students Using a PAR Approach Tru Storey
Source:
UC Davis / VM: Anat Physio & Cell Biology / 2025
Topics:
No topics listed
Co-authors:
William Stoehr