Poll
Zhang
Sponsor: Anthony Albanese, M.D. MED: Int Med - Gastroenterology Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) represent leading worldwide causes of end-stage liver disease. Currently, detection and diagnosis of MASLD/MASH can be screened by quantitative ultrasound (US) and magnetic resonance imaging (MRI) among other methods. While screening by US represents an affordable, accessible, and quantitative method for estimating liver stiffness and fat, US measurements can be limited by technical or clinical factors. MRI can more accurately quantify hepatic stiffness and fat, but can be costly and difficult to obtain. Our prospective research study enrolled 101 patients with obesity and/or diabetes at VA Palo Alto for quantitative US and same-day MRI to examine clinical and technical factors that can affect the diagnostic quality of quantitative liver ultrasound in MASLD/MASH screening. To evaluate the screening effectiveness for MASLD/ MASH, we aim to compare quantitative US measurements of liver stiffness (auto-point shear wave elastography or pSWE) and fat (Ultrasound-Derived Fat Fraction or UDFF) to quantitative MRI. Almond Shells: An Innovative Solution for Phenolics in Winery Wastewater
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Poll Zhang
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California is the main producer of almonds and wine in the U.S., generating significant waste, primarily almond shells (ASP) and winery wastewater (WWW). WWW, rich in dissolved sugars and phenolic compounds, requires costly and energy-intensive treatments before environmental disposal. The high concentrations of phenolics in WWW are not readily biodegradable and hazardous to microorganisms. However, treatment of WWW by ASP has been shown to bind up to 0.33 mg phenolics per gram of dry ASP due to its porosity and composition of lignin, cellulose, and hemicellulose. Recovered phenolics offer an accessible and diverse source of phenolic compounds for future applications. This study focuses on optimizing the recovery of phenolic compounds from WWW- enriched ASP. Different ethanol: water ratios (v/v) and ASP: ethanol ratios (m/v) were analyzed via reverse-phase High- Performance Liquid Chromatography coupled with a diode array detector (HPLC-DAD). Phenolics recovery ranged from 37% to 49%, with the optimal condition using 50:50 (v/v) ethanol: water with 1:5 (m/v) ASP: ethanol ratio within the model WWW system. WWW was also collected to test the applicability of recovery. This study highlights that the recovery of phenolics is effective and could be used in future food and cosmetics. UC Davis 36 th Annual Undergraduate Research, Scholarship and Creative Activities Conference 311 The Role of PRC2-mediated H3K27me3 in the Development of Spermatogonial Stem Cells Tina Zhang
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UC Davis / Food Science & Technology / 2025
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Poll Zhang