Rohan
Marde
Sponsor: Loralyn Taylor, Ph.D. MED: Public Health Sciences Postpartum depression (PPD) is a prevalent maternal mental health condition that disproportionately affects low-income women of color in the United States, yet remains significantly underdiagnosed and undertreated in this population. This project presents a conceptual analysis examining PPD as a measurable outcome, supported by secondary data synthesis of national maternal health datasets using indicators such as Edinburgh Postnatal Depression Scale (EPDS) scores, prevalence estimates, and rates of screening and treatment utilization. Evidence demonstrates that low-income birthing people of color experience heightened exposure to PPD-associated stressors while simultaneously facing systemic barriers limiting access to timely and culturally responsive care. This project analyzes how key social determinants of health (SDOH), including socioeconomic instability, limited access to culturally competent care, and structural racism and gender bias within health systems, interact to sustain inequities in PPD identification and treatment. A conceptual model illustrates these pathways. This project also identifies evidence-based, actionable opportunities for interventions in order to strengthen standardized screening practices, expand culturally responsive care and community- based prevention models, and inform maternal mental health policy. By addressing the structural drivers of inequity, this project aims to improve maternal mental health and reduce long-term adverse outcomes for postpartum individuals and families. Single Cell-Level Transcriptomics Signatures of Autism Spectrum Disorder
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Authors:
Rohan Marde
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Autism spectrum disorder (ASD) is a complex, heterogeneous set of neurodevelopmental disorders characterized by difficulty socializing, repetitive behaviors, and delayed speech or communication. ASD prevalence in children has increased almost five-fold since the year 2000, but the etiology of the disease remains unknown. We performed single nuclear RNA sequencing (snRNA-seq) on human post-mortem cortex samples taken from an age-matched cohort of five typical development (TD) individuals and 5 individuals diagnosed with ASD. We then identified significant cell type-specific differentially expressed genes (DEGs) between the ASD and TD cohorts, revealing differences in gene expression across all cell types. Layer two and layer three intratelencephalic neurons showed especially broad upregulation, suggesting that excitatory neurons may experience a loss of gene regulation in individuals with ASD. Furthermore, our analysis revealed that the two most upregulated transcripts in the ASD cohort were long non-coding RNAs (lncRNAs) that have not previously been shown to be associated with ASD, ENSG00000278996 and ENSG00000280441. ENSG00000278996 has been shown to be upregulated in liver transplant recipients with post-transplant non-alcoholic steatohepatitis, and ENSG00000280441 has not been studied. Our findings suggest that upregulation of specific lncRNAs and loss of transcription regulation in excitatory neurons may contribute to the symptoms of ASD. Preserving Gurung Vernacular Architecture: A Roundhouse Exhibit at the Gaurase Bhume Aama Samuha Local History Museum Alexandra Mariotti
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UC Davis / MED: Medical Microbiology&imm / 2026
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Rohan Marde