Ruby
Mendoza
Sponsor: Francis Mcnally, Ph.D. Ag Molecular & Cellular Bio During female meiosis, the spindle is asymmetrically oriented at the cell cortex to expel three-fourths of the genetic material into polar bodies. Previous experiments in C. elegans indicate the spindle is pushed to the cortex by the inward packing of organelles by kinesin-1, a microtubule motor protein. In kinesin-1 null mutants, the most abundant organelles, mitochondria and yolk granules, are not packed and the meiotic spindle is centered in the cell. Spindle positioning is rescued in kinesin-1 null mutants that express a mitochondria-only kinesin, however, yolk granules were not packed by the mitochondria-only kinesin. In mitochondria-only worms, the mitochondria remain packed in a tight ball even after the inversion of microtubule orientation at the end of meiosis. We hypothesize that the mitochondria-only kinesin is causing mitochondrial fusion into a network that is more effective at pushing the spindle outward even in the absence of yolk granule packing. We will test this hypothesis by depleting fzo-1, a protein required for mitochondrial fusion, via RNAi and measuring the distance of the spindle from the cortex. Our preliminary results indicate a statistically significant decrease in mitochondrial length after fzo-1(RNAi) and spindle positioning measurements are in progress. Earthen Materials Library Nook
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Authors:
Ruby Mendoza
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The demand for a vast quantity of new buildings to address the need for increased housing and living standards grows simultaneously with the need to alleviate global warming and mass production of carbon emissions. To investigate solutions to these environmental challenges in design, this project explores how earthen materials naturally provide innovative properties for sustainable construction. The process involves using a combination of alternative low-carbon construction materials and methods to explore the material culture of natural building materials in an effort to move toward a more circular economy within architecture, and away from the industry's continual reliance on energy-intensive materials like steel and concrete. The final Earthen Materials Library presents an interactive display of bio-material samples, including cob, hempcrete, and straw bale, among others, in addition to a bench constructed with different natural building materials and techniques. The process was informed by a variety of technologies and practices researched in the field of vernacular architecture, which can be defined by a long history of empirical practices that have led to regionally-specific construction techniques that implement raw natural materials. Experimentation includes a variety of processes including 3D modeling, joinery techniques, woodworking, lamination, and plastering. The Role of DH44R1 and DH44 in Regulating Body Temperature Rhythms in Drosophila Berenice Merida Mateo
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UC Davis / Department Of Design / 2026
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Ruby Mendoza