Dena
Pham
Sponsor: Crystal Rogers, Ph.D. VM: Anat Physio & Cell Biology Neural crest (NC) cells are a vertebrate-specific population of multipotent embryonic stem cells that give rise to over 30 adult cell types, including craniofacial cartilage, bone and peripheral nervous system. During development, NC cells undergo epithelial-to-mesenchymal transition (EMT), altering cell-cell adhesion to delaminate from the neural tube and migrate throughout the embryo. Processes are regulated by neural crest gene regulatory network (GRN). Dynamic regulation of cadherin- mediated adhesion is essential for NC EMT and migration. Neural cadherin (NCAD) is downregulated to permit delamination, while epithelial cadherin (ECAD) is maintained in early migratory NC cells. SOX10- a key transcription factor within the NC GRN, is required for NC migration, yet its interactions with cadherins remain poorly understood. We observed that SOX10 overexpression causes premature differentiation and arrested NC migration in chicken embryos, while promoting premature NC migration in quail embryos. We hypothesized that species-specific phenotypes arise from differential regulation of cadherin expression. We performed ex ovo injections of a SOX10-GFP expression plasmid into chicken and quail embryos at gastrulation stage and analyzed NCAD and ECAD protein expression during NC migration using immunohistochemistry. Results demonstrate that SOX10 overexpression drives divergent cadherin expression patterns across species, highlighting a conserved factor with species-specific regulatory outcomes. Evaluating Vignette Usage in Moral Judgment Research: A Scoping Review
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Dena Pham
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Since the mid-twentieth century, researchers have been using short scenarios to assess adolescents' and emerging adults' moral judgments. This study investigates vignette usage in the study of moral judgment and reasoning across ages 13-25. By examining the topics studied, vignette structure, and populations studied, we will provide insight into new areas of future research. Specifically, we are conducting a scoping review, which is an iterative process to understand the existing literature and identify gaps in knowledge for future research. After a robust search strategy, articles were screened in accordance with the following criteria: used written vignettes, studied ages 13-25, and assessed moral judgment. Screening consisted of two stages: title/abstract and full-texts. Finally, we are extracting data on each study's sample demographics, vignettes, recording study design. We plan to provide descriptive statistics of the extracted data, alongside analyzing longitudinal trends in topics studied. In doing so, we will highlight knowledge gaps in the field and inform future research directions on moral judgment. Labor Standards in Emerging Markets and U.S. Foreign Direct Investment in Technology Manufacturing Ha-Khanh Pham
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UC Davis / Psychology / 2026
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Dena Pham