Authors:

Lauren Ellis

Date Created:

Not specified

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About Paper:

The Microscale Tissue Models Project aims to create a series of histology-based 3D polygon mesh models to accurately test the toxicity levels of various organs when dosed with alpha and beta- particle emitters for radiopharmaceutical cancer therapy. The organ being analyzed in this project is the salivary gland, specifically the parotid gland. The salivary glands are a pair of organs on either side of the jaw that are important for proper digestion and immune function. When radiopharmaceuticals or ionizing radiation are used too closely to the glands, the organs can be permanently damaged. Thus, providing doctors with accurate models of how salivary glands are affected by various dosages of both alpha and beta-emitters will allow them to treat cancer effectively without causing unnecessary organ toxicity. To create this model, a representative set of salivary gland histology slides were placed in order and imaged. Following imaging, the significant structures such as the striated ducts and blood vessels will be segmented and then reconstructed using CAD software. The model will then be validated against known anatomical values in literature. Finally, the model will undergo radiation simulation in PHITS to assess microscale damage due to various systemic radiation doses. 121

Source:

University of Florida / 2024

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No topics listed

Co-authors:

Lauren Ellis