Authors:

Madison Chubb

Date Created:

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About Paper:

Pancreatic cancer is one of the most lethal cancers, with a 5-year survival rate of 5-10%. Metastasis is one of the most daunting challenges that exists as a barrier to reduce cancer-related mortality. Circulating tumor cells (CTCs) are cancer cells that shed from existing tumor lesions and travel through the blood circulatory system, potentially leading to cancer metastasis. CTCs are effective biomarkers that have shown significant utility with respect to tracking cancer progression and patients' responses to treatment. However, CTCs detection is limited by its extreme rarity among billions of normal blood cells. Here we report a microfluidic device that integrates both immunoaffinity-based isolation and size-based filtration to achieve a high capture efficiency of CTCs from whole blood. In this work, we utilized the microfluidic devices to monitor CTC count along the neoadjuvant treatment period for pancreatic cancer patients. This poster shows the design and working principles of our microfluidic devices in capturing CTCs and subsequent analysis. 429

Source:

University of Florida / 2024

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No topics listed

Co-authors:

Madison Chubb