Authors:

Brown Researcher (C12)

Date Created:

Not specified

Course Title:

Professor:

Not specified

About Paper:

patients demonstrate superior right ventricular (RV) function and survival compared to males. This sex paradox points toward complex, underexplored biological mechanisms. This project integrates converging areas of inquiry: sex steroids, adiposity, immune tolerance, and hepatic signaling, in an effort to elucidate contributors to sex-specific PAH pathogenesis. Hepatic-derived factors—particularly disrupted BMP9/10 signaling, altered estrogen metabolism, and systemic inflammation—are explored as mediators of portopulmonary hypertension (PoPH) and PAH. Literature-based analysis, along with experimental exposure to molecular and clinical tools (e.g., qPCR, western blotting, 6MWT, DEXA, body composition), forms the basis of this multidisciplinary investigation. Though data acquisition remains ongoing, the integration of hepatic dysfunction, immunobiology and body composition offers a novel lens into the inter-organ, sex-informed pathobiology of PAH. These findings may ultimately inform therapeutic strategies that recognize immune, sex steroid and hepatic networks as critical modifiers of pulmonary vascular disease. Austin Courtney:

Source:

Oregon State University / Leadership Alliance-Summer Research Early Identification Program (SR-EIP)

Topics:

No topics listed

Co-authors:

Brown Researcher (C12)