Authors:

Sarah Bahsoun

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significant increases in proliferation for PPI-TCR+ Tregs compared to polyclonal Tregs. Finally, we used in vitro suppression assays to measure CD8+ and CD4+ T responder proliferation by flow cytometry and observed that PPI-TCR Tregs demonstrated improved suppressive capacity compared to polyclonal Tregs after four days of co-culture. This data suggests PPI-specific TCRs can improve in vitro Treg suppressive and proliferative capacity during antigen-specific stimulation with

Source:

University of Florida / Sarah Bahsoun, Emily Miller, Aidan Smith, / 2023

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Co-authors:

Sarah Bahsoun