Hadil
Djadri
Sponsor: Li-en Jao, Ph.D. MED: Cell Biology & Human Anat The centrosome acts as the main microtubule-organizing center in animal cells. Its function is important for spindle organization and chromosome segregation. Intriguingly, primary microcephaly, a disorder of brain development that results in smaller brain, is caused by recessive mutation of several genes that encode centrosomal proteins. It is unknown how centrosomal dysfunction could lead to brain-specific defects such as microcephaly. Given the high degree of conservation between human and zebrafish genes, the fast embryonic development, and the ease of genetic manipulation and phenotypic analyses, we use the zebrafish model to study the etiology of primary microcephaly and related disorders. Here we used the CRISPR technology to mutate cep215 and pcnt, two centrosomal genes whose human orthologs are linked to primary microcephaly and microcephalic osteodysplastic primordial dwarfism type II, a disorder characterized by microcephaly and short stature. We have developed a genotyping strategy to quickly screen for wild-type, heterozygous, and homozygous mutant fish after fin biopsy. We are in the process of characterizing the cellular and developmental phenotypes of these mutant embryos. We believe that these zebrafish mutants we generated would be valuable models to study the pathogenesis of tissue-specific phenotypes caused by centrosome defects. NYT MEDIA PROJECT: The Algerian War of Independence Through the Lens of the New York Times
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Authors:
Hadil Djadri
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How did the New York Times (NYT) represent Algeria in the 1960s? To answer this question, I used ProQuest to analyze 42 articles, of which 10 were relevant. This research draws parallels between the Algerian independence movement and the broader historical context in the 1960s to better evaluate how Algeria was perceived in the media. The 1960s was integral in North African and Middle Eastern history because independence movements shifted the perception of Arabs from being subordinate to their colonial powers to being autonomous people. As a leading American newspaper, the NYT's portrayal of Algeria was influential in shaping worldwide perception of the Algerian war and the people fighting it. The NYT's representation largely reflected the United States' foreign policy interests in decolonization and the Cold War. Reference to Algerians as "rebels," "insurgent nationalists," and "rebel terrorists" also framed the Algerian cause as a rebellion, which discredits the struggle for self-determination after enduring French colonial rule for more than one hundred years. This research is part of a long-term analysis project of the NYT from 1850 to the present from the Suad Joseph Lab. The project analyzes the representation of Islam and Muslims over 150 years. Specific Protein Domains are Required for Localization and Function of MHCI H2-Kb in Neurons Terilyn Do
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UC Davis / Anthropology / 2023
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Hadil Djadri