Katharina
Lenz
Sponsor: Cecilia Giulivi, Ph.D. VM: Molecular Bio Sciences Age-Related Macular Degeneration (AMD) is a retinal disease that leads to central vision loss. The disease manifests as an accumulation of lipid and proteins plaque in the form of extracellular lipid deposition known as drusen or intracellular lipid accumulation presenting as punctate lesions, culminating in macular degeneration. Primates are the only mammals to possess maculae essential for sharp central vision, making them crucial models for AMD research. The macula, rich in mitochondria, is susceptible to environmental influences (such as sunlight exposure and dietary habits) and genetic factors that may contribute to mitochondrial damage, influencing the onset and progression of degeneration. To investigate, we analyzed mitochondrial morphology in retinal pigment epithelial cells of healthy rhesus macaques versus those with drusen or punctate lesions. Our findings revealed disrupted mitochondrial morphology in AMD samples, particularly those with drusen or punctuated deposits, exhibiting blunted fusion, a more circular shape, and diminished content compared to normal animals. These observations shed light on the potential role of mitochondrial dysfunction in AMD. Understanding this mechanism could guide the development of future treatments and preventive strategies targeting mitochondrial aspects of AMD. History of Anthropological Research on the Sami of Norway
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Katharina Lenz
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My research takes a historical approach to understanding Indigenous Sami in the Sápmi region of Norway. My project aims to identify changes in anthropological research topics, and how Norway's governmental policies, increased resource extraction, Sami self-determination, climate change, and tourism have influenced the type of research undertaken by anthropologists. Initial data was generated through issue-by-issue culling of articles published in anthropology's flagship journal, American Anthropologist, founded in 1888, and from the only anthropology journal focused on the circumpolar north, Arctic Anthropology, founded in 1962. American Anthropologist published 29 articles about the Sami in the following decades: 1910s (n=1), 1920s (n=2), 1940s (n=1), 1950s (n=3), 1960s (n=7), 1970s (n=3), 1980s (n=2), 1990s (n=6), 2000s (n=4). There is a near even split between the number of publications prior to 1970 and those published after 1970. Although started in 1962, Arctic Anthropology, has more publications overall than American Anthropologist given its geographic focus: 1970s (n=6), 1980s (n=3), 1990s (n=3), 2000s (n=5), 2010s (n=21). Using key search terms identified in this initial analysis, I will undertake a Google Scholar search of published articles over the past century (1920-2020) to explore the history of Sami research in Norway. UC Davis 35 th Annual Undergraduate Research, Scholarship and Creative Activities Conference 148 Using Genetic Screenings to Identify Novel Genes Associated with NAD+ Metabolism and its Regulation in the Model System Saccharomyces cerevisiae Althea Leones
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UC Davis / Anthropology / 2024
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Katharina Lenz