Authors:

Victoria Zafra Marquez

Date Created:

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About Paper:

Human body temperature increases during the daytime, decreases during the nighttime, and starts to increase before dawn (morning anticipation). These daily changes in body temperature, body temperature rhythm (BTR), is controlled by the circadian clock genes. However, the mechanisms of BTR regulations in mammals are still unclear. Our laboratory previously discovered that fruit flies, Drosophila melanogaster, which are small ectotherms, regulate their BTR by selecting appropriate environmental temperatures throughout the day. Our research demonstrated that the fundamental regulatory mechanisms of BTR are conserved between mammals and Drosophila. Thus, we examined the role of Drosophila circadian clock neurons in BTR to determine its regulatory mechanisms. To test this, we suppressed the clock function in the respective core clock neurons using tim-CRISPR and the UAS/Gal4 binary gene expression system, and assessed their BTR in 12-hour light/dark cycles. We discovered that the clock suppression disrupted the morning anticipation in dorsal neurons (DNs: DN1a, DN1p, and DN2), but not in ventrolateral neurons (LNvs). Our findings suggest the BTR regulations primarily rely on the activity of DNs, and LNvs have subordinate roles in the BTR regulations. Thereby, we are closer than ever to understanding the mechanisms of BTR in both Drosophila and humans. The Politics Behind AI: How Political Beliefs Drive Opinions on Artificial Intelligence in California Aleena Zaheer

Source:

UC Davis / Neuro Physio & Behavior / 2024

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Co-authors:

Victoria Zafra Marquez