Authors:

Yaejin Kim

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About Paper:

Olfactory loss is a common early symptom of Alzheimer's disease (AD). Human population studies have suggested infections, including SARS-CoV-2 (Cov2), that cause inflammation of the olfactory system may contribute to the onset of AD. We previously found CoV2 infection in the Olfactory Epithelium (OE) induces an upregulation of antiviral response. We hypothesize that this viral induced OE inflammation propagates into the olfactory bulb (OB) portion of the brain and interacts with the neuropathology in an AD model. To investigate, we performed spatial transcriptomic analysis using 10x Genomic Xenium Analyzer. Mice were either wildtype (C57BL6/J) or an AD model (5xFAD), receiving nasal inoculation with a mock PBS control or CoV2 at 10e5 PFU. OBs were examined at 2 days or 3 months post-inoculation. Mouse 5K and mouse brain probes were selected to examine gene expression patterns. Probes were hybridized and amplified to identify on a single cell resolution map. We obtained high-quality data that identified inflammation along the olfactory nerve into the OB and corresponding microglia activation in both CoV2 infected WT and AD mice. Further bioinformatic studies will be conducted to compare and identify transcripts and their gene ontology to signify the interaction between the AD and CoV2. Effects of Neighborhood Cohesion on the Relationship Between Discrimination, Neighborhood Quality, and Depressive Symptoms in Mexican-Origin Mothers.  James Kimsey

Source:

UC Davis / MED: Cell Biology & Human Anat / 2025

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Co-authors:

Yaejin Kim