Travis
Choi
Sponsor: Eric Dickson, Ph.D. French & Italian You may have heard forms like periodt or clock it during your daily social media scroll. These forms are often spoken by influencers or the lyrics of songs that play in the back of short- form content. The associations held with these forms in House Ballroom Communities (HBCs) and the greater BIPOC cultural space demonstrates a different linguistic phenomena altogether. The use of forms that are associated with joy and resistance in BIPOC spaces, and the use of forms categorized as African American Vernacular English (AAVE), by individuals with different racial identities demonstrates the hegemonies of race and monetization in American society. In this presentation I will explore the racial hegemonies demonstrated through specific examples of forms used in social media. The examples presented in the presentation are representative of the larger linguistic phenomena in HBCs and appropriated in mainstream culture, demonstrating the hegemonies of race. To combat these hegemonies, one must acknowledge that linguistic trends or phenomena are rarely from a coincidence. Characterizing C-peptide Aggregation Using Single-Molecule, Super-Resolution Fluorescence Microscopy
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Travis Choi
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Protein aggregation is associated with over 25 diseases, including Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Aggregation occurs when misfolded proteins "stick" to one another and accumulate into larger species to form insoluble fibrils and amorphous aggregates. Characterizing the factors that influence protein aggregation is crucial for understanding disease mechanisms and developing treatments. In our experiments, we have examined the effect of chemical environment on the formation of C-peptide aggregates at the nanoscale using single- molecule, super-resolution fluorescence microscopy. C-peptide, a 31-amino acid peptide produced by pancreatic β-cells alongside insulin, maintains important physiological roles, and appears to interact with the aggregation-prone proteins insulin and islet amyloid polypeptide. We have found that aggregate type (fibrillar vs. amorphous), size, and heterogeneity depend on peptide concentration, pH, surfactants, metal ion concentration, and temperature. In combination with structural information from circular dichroism, super-resolution fluorescence microscopy measurements allow us to build a detailed understanding of C- peptide aggregates at the molecular level, providing insight into both biological function and aggregation mechanisms. This study of physiologically relevant peptides may also inform our understanding of aggregation processes and mechanisms in other protein aggregate diseases, providing a pathway for future research and cures. Effects of Gamification in Peer-Led Laboratory Instruction on Student Technical Comprehension and Engagement Zoe Choi
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UC Davis / Chemistry / 2026
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Travis Choi