Authors:

Seungbin Kwon

Date Created:

Not specified

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About Paper:

Understanding the mechanical characteristics of tissue is critical to advance diagnostic methods and medical treatment. However, most mechanical testing methods for tissue are performed ex-vivo. This disregards the natural environment of tissue and hinders the preservation of homeostasis and properties of tissue. A different approach is to use magnetically responsive membranes. Previous studies used magnetically aligned platelets to create synthetic materials with biologically inspired microstructures and elastomer composites that generate magnetic torques. We project to develop a remotely actuated polymer membrane containing magnetically responsive particles which will be adhered to biological tissue in vivo and stimulated by magnetic fields. In this study, we develop a manufacturing method for casting a Polydimethylsiloxane (PDMS) and Nickel composite membrane and perform mechanical characterization and adhesion tests. This approach preserves the mechanical properties of tissue, addressing the common complication of ex-vivo testing. PDMS-nickel membranes are cast in specifically designed 3D printed molds with microscope slides. The nickel platelets are magnetically aligned by a rotating permanent magnet during curing process. We mechanically test the manufactured PDMS-nickel membranes and perform preliminary adhesion tests with biological tissue. Equibiaxial testing is performed with the PDMS-nickel membranes to find the range of moduli of elasticity and numerous adhesives were assessed in adhering the membranes to mouse skin. Based on our investigation of the material properties and magnetic response of cured PDMS-nickel membranes, this study offers new insights for alternative approaches to ex-vivo research of tissue.

Source:

Purdue University / 2023

Topics:

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Co-authors:

Seungbin Kwon