Authors:

Nicholas Buffo

Date Created:

Not specified

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About Paper:

Articular cartilage is a connective tissue that lines the surfaces of bones and provide a smooth and lubricated surface to handle high joint loads and reduce friction. Osteoarthritis, a degenerative whole joint disease, including the degeneration of articular cartilage has affected millions of people worldwide. Early indications and detection of osteoarthritis are still being developed, but new imaging techniques have promising results. Specifically, sodium (23Na) MRI, through analysis of sodium standards and signal from the scan, can provide quantitative data about tissue content through its relationship to glycosaminoglycans (GAG) and fixed charged density. GAGs are highly negatively charged sidechains covalently linked to a protein backbone - this complex constitutes a proteoglycan. 23Na is responsible for maintaining the charge and osmotic balance against the highly negatively charged GAGs. Thus, 23Na density tracking can give rise to detection of cartilage degeneration through diminished sodium signal. Currently, 23Na MRI's translation is hindered by long scan times and poor image quality (e.g., low signal to noise ratio (SNR) and spatial resolution). Our dual-echo ultra- short echo time 3D-rosette k-space trajectory aims to improve SNR and spatial resolution in comparison to an industry-standard 23Na MRI technique using radial k-space acquisition. This research will explore the validation of inter-scan variance in a 6-12-month period of the 23Na MRI analysis of industry-standard radial acquisition techniques compared to our dual-echo UTE 3D-rosette k-space trajectory. Examining the inter- and intrascan variance with our novel rosette UTE sequence will ensure that this sequence is repeatable for further studies and may be utilized in the analysis of these studies.

Source:

Purdue University / 2023

Topics:

No topics listed

Co-authors:

Nicholas Buffo