Authors:

Amelya Fox

Date Created:

Not specified

Course Title:

Professor:

Not specified

About Paper:

Cardiovascular disease (CVD), including myocardial infarction (MI), is the leading cause of death worldwide for both sexes. MI occurs when blood flow to the myocardium is obstructed, often by an occlusion of the coronary artery. The infarcted region typically becomes stiff and fibrous as healthy myocytes are replaced by scar tissue, and the heart remodels to compensate. Dilation and wall thinning in the ventricle during the remodeling process can lead to heart failure. Sex differences in the mechanisms of myocardial infarction and cardiac remodeling exist but are poorly understood, leading to sex-based discrepancies in diagnosis and prognosis. In this study, we seek to develop a better understanding of the physiological sex differences that govern the heart's adaptation to injury and progression to heart failure. We induced MI in a mouse model using permanent ligation of the left coronary artery (LCA) in both and males (n=7) and females (n=8). We then imaged the left ventricle of the heart using 2 and 4-dimensional ultrasound (4DUS) at various time points up to 28 days following the infarct, analyzing the images to calculate metrics of left ventricular function. The resulting data will be statistically analyzed to determine if there are differences between the male and female groups. Our results and this methodology can likely be used to inform further studies aimed at achieving equitable health outcomes for CVD patients of both sexes.

Source:

Purdue University / 2023

Topics:

No topics listed

Co-authors:

Amelya Fox