Authors:

Taylor Ortiz

Date Created:

Not specified

Course Title:

Professor:

Not specified

About Paper:

Fatty acids exist throughout the body in numerous forms performing a variety of functions essential to the host. While fatty acids are necessary for survival due to their roles in metabolism, insulation, and regulation of hormones, there are some forms of fatty acids that prove to be dangerous when exceeding specific quantities. Very long chain fatty acids, which are found in tissues, the liver, the brain, and other specific areas, prove to be damaging in larger quantities, contributing to neurodegenerative disorders such as Adrenoleukodystrophy and Alzheimer's disease. The gene for orchestrating the construction of these prolonged fatty acids is elongation of very long chain fatty acid 1 enzyme (ELOVL1). This study investigates the possibility of ELOVL1 as a therapeutic target for lowering VLCFAs and their precursor LPC (lysophosphatidylcholine). We will use particular drug treatments that are intended to block ELOVL1 activity. We aim to illustrate the importance of these compounds in alleviating VLCFA-associated pathologies by examining the effects of these treatments on ELOVL1 and subsequent VLCFA levels using HEK 293 cells. Lipids run in triple quad mass spectrometry will be analyzed by an in-house generated software and incorporated into the poster.

Source:

Purdue University / 2023

Topics:

No topics listed

Co-authors:

Taylor Ortiz