Authors:

Jinyang Du

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About Paper:

Medical ultrasound imaging is a widely used diagnostic technique for visualizing internal organs and vasculature. However, it possesses a limited contrast resolution which can impede the accurate identification of structures. The advent of ultrasound contrast agents (USCAs) has increased contrast and improved the diagnostic power of ultrasound imaging. Although gaseous-core USCAs have been approved for clinical use, liquid-core USCAs have demonstrated higher stability. Numerous manufacturing methods exist, though it remains uncertain which method yields the best results. Therefore, there is a need to identify which parameters change with respect to the manufacturing technique to identify the optimal manufacturing method. This project aims to address this issue by identifying the optimal materials and manufacturing methods, including shaking, double syringe technique, ultrasonic dispersion, and ultrasonic waterbath, for liquid cores to develop USCAs for clinical use. The study will explore the various compositions of liquid cores while using lipids of the same composition as the gas core shell to optimize the function of liquid core USCAs. The goal of our study is to refine the best fabrication and materials by first assessing monodispersity using DLS as well as conducting cytotoxicity tests and ultrasonic echo tests in vitro to assess criteria such as toxicity, stability, echogenicity, and acoustic interactions, and then comparing USCA made through different methods. In addition, this study will further determine the relationship between dose and viability and test ultrasound echogenicity in live mice by using the optimal liquid core USCA.

Source:

Purdue University / 2023

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Co-authors:

Jinyang Du