Authors:

Dhruv Mendpara

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About Paper:

Continuous dry granulation is one of the common processes used for pharmaceutical tablet manufacturing which involves feeder, blender, roller compactor (RC) and tablet press. Compared to wet granulation, dry granulation approach allows the usage of heat and moisture-sensitive materials opening up the possibility of applying granulation technique on various other powder materials to improve qualities such as flowability and bulk density. The process of RC involves compression of powder by two counter-rotating rolls, then milled into granules before using them to make tablets. For this project, the effect of the change in the type of blenders at different process parameters such as rotor-screen gap (RSG) and hydraulic pressure on the bulk density and particle size distribution of the granules will be focused. Alexanderwerk WP120 RC was employed to collect sample granules at different conditions which were then analyzed for the distribution of fines and granules in each sample using CANTY SolidSizer. A blend mixture of 10% Acetaminophen (APAP) and 90% Microcrystalline Cellulose (MCC-102) was used with the design of experiments being to operate the RC with Tote blender (batch blending based on weight) and continuous Gericke blender (blending based on flowrate) at RSG 0.2, 0.5, 1.0, and 1.5 mm with the hydraulic roll pressure at 30 bar and 60 bar each. The results show that at both pressures, the number of fines decreases as the RSG decreases for each blender type. However, the number of fines produced for each blender type varied indicating that blending approach can impact the granule properties.

Source:

Purdue University / 2023

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Co-authors:

Dhruv Mendpara