Authors:

Deniz Eksioglu

Date Created:

Not specified

Course Title:

Professor:

Not specified

About Paper:

Neuromodulation involves surgically implanting stimulating electrodes into specific neural regions to modulate faulty neural circuits, treating neurological disorders such as Parkinson's disease, essential tremors, and chronic pain. The implanted electrodes generate artificial action potentials across the axons of stimulated nerves, modulating neurological behaviors. However, implanting stimulating electrodes poses risks, such as foreign body response, corrosion, or the release of toxic substances that can harm surrounding cells. Moreover, these electrodes must deliver high levels of electrical charge, which could cause severe damage due to their high resistance and inability to store enough charge because of their size. To mitigate these risks and maximize stimulation efficiency, conducting polymers can serve as an interface between the metal substrate and biological tissue. These polymers exhibit high charge injection capacity and superior biocompatibility due to their porous structure and capacitive charge transfer mechanism under physiological conditions. In this study, we developed a poly(3,4-ethylene-dioxythiophene): poly(4-styrene-sulfonate) (PEDOT: PSS)-coated stimulating electrode and evaluated its electrochemical properties and safety limits to determine stimulus parameters using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and voltage transient (VT) experiments. Cathodic charge storage capacity (CSCc), impedance at 1 kHz, and cathodic charge injection limit (CIL) were sequentially extracted as features from the experimental results. While the results indicate that PEDOT: PSS is a promising material for stimulation, the damage observed on the electrode after the voltage transient test suggests that further studies are needed to improve adhesion between PEDOT: PSS and the underlying metal electrode. Keywords: Neuromodulation; PEDOT: PSS; Cyclic Voltammetry; Electrochemistry Impedance Spectroscopy; Voltage Transient

Source:

Purdue University / 2024

Topics:

No topics listed

Co-authors:

Deniz Eksioglu