Authors:

Katie Wing-See Chan

Date Created:

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About Paper:

Beta1 integrin is involved in cellular proliferation and drug resistance across various cancers such as glioblastoma, liver cancer and breast cancer. This integrin facilitates cell adhesion to the extracellular matrix (ECM), which promotes cell survival and proliferation through signaling pathways such as FAK, PI3K, and ERK/MAPK. Beta1 integrin's interaction with ECM components regulates cell cycle progression and apoptosis evasion, which contributes to enhanced proliferation rates. Beta1 integrin overexpression is also associated with drug resistance in cancer cells. Our findings suggest that beta 1 integrin is upregulated in more densely populated cultures, which may have implications in drug resistance. Western blot analysis was used to quantify the levels of beta 1 integrin in various cell strains associated with drug resistance. Keywords: [no keywords provided]

Source:

Purdue University / 2024

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Co-authors:

Katie Wing-See Chan