Authors:

Daniel Ethan Kelley

Date Created:

Not specified

Course Title:

Professor:

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About Paper:

Irritable bowel syndrome, which affects 25 to 45 million patients in the US alone, has limited medical treatment and often requires additional lifestyle adjustments for patients receiving such treatment. It is one example of colon related diseases that pose unique difficulties to treatment, since orally administered systemic drugs must pass through the entire digestive system to reach their target, raising the likelihood of associated side effects. A microrobot system has the potential to provide direct, targeted drug release within the colon. The microrobots can translate through the lumen of a colon by moving end-over-end in a tumbling motion. This motion is achieved with induction by using the microrobots, which contain a magnet, over a stage with a motorized spinning permanent magnet. They also have a hollow interior to carry a drug solution and a port covered in thermally sensitive paraffin wax. A newly improved artificial rat colon, modeled from 3D ultrasound images from a living rat, served as the setting for studies on the microrobot's release of a mock drug. Heating with focused ultrasound was characterized, with temperature changes up to 10°C achieved. Focused ultrasound was then demonstrated as a viable means to release the mock drug from the microrobot within the artificial colon. Next steps include quantification of release and testing the focused ultrasound-driven release in situ and in vivo. Keywords: Microrobots; Ultrasound; Drug Delivery

Source:

Purdue University / 2024

Topics:

No topics listed

Co-authors:

Daniel Ethan Kelley