Authors:

Louden James Maciag

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About Paper:

As people grow older, their risk of high blood pressure increases, potentially leading to side effects such as kidney disease and heart failure. Due to the prevalence of these diseases, the manufacture of drugs to treat high blood pressure, such as propranolol become increasingly important. Improvements in synthesis of propranolol, that also reduce byproduct formation due to epoxide ring opening in its intermediate is sought. To ensure more effective synthesis, this research aims to eliminate the byproducts that stem from propranolol creation using continuous flow synthesis. Our initial phase consisted of determining the dimensions for our flow apparatus, which derived from a previous lab member's research. Judicious selection of the reactor length and overall reaction time revealed the ability to conserve the epoxide ring and prevent ring opening. Shortening the residence time of the reaction from 60 minutes to 30 minutes was then tested to see how it would affect purity and yield of the sample. Results indicated a drop in purity from 90% to 88% and a decrease in yield from 65.34% to 42.04%. Further work includes using the techniques learned from this experiment to effectively add the epoxide ring to other compounds, such as carboxylic acid derivatives. We plan to do this through the use of a packed bed reactor within the flow apparatus in order to act as a base instead of adding it via syringe to better prevent ring opening within the reaction. Keywords: Propranolol; Epoxide Ring; Flow Chemistry; Residence Time

Source:

Purdue University / 2024

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Co-authors:

Louden James Maciag