Authors:

Julia Janina Szela

Date Created:

Not specified

Course Title:

Professor:

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About Paper:

Point-of-care (PoC) health screening tools, such as paper-based lateral flow immunoassays (LFIA), are widely used for the categorical detection of viral infections. However, LFIA are ill-suited to quantifying the relative expression of nucleic acids or proteins when identifying a patient's viral status, lacking appropriate specificity. Enhancing current paper-based methods through the integration of electrochemical techniques would allow for improved quantifiability and specificity of biomolecular binding. Here we used a laser treatment process to make electrically conductive paper traces while avoiding the use of inks or metals. We investigated the effect of laser fluence on resistivity by adjusting varying levels of power and speed, allowing us to characterize the effects of these traces. These traces were designed to press fit into common USB type-C interface, so to leverage the integrated analog-to-digital hardware of smartphones. Using a CO2 laser cutter to create laser- induced graphene (LIG) on paper surfaces not only makes the device disposable, but also allows for the development of a USB-C. We found that characterizing the electrical properties of the LIG contributed to the design of a capacitance-based biosensor that is compatible with a USB type-C interface. With this, it will allow us to measure of capacitance of an antibody bound electrode versus an unbound reference electrode through signal decay time. This technique highlights its promise for developing low-cost and disposable diagnostic products extensible to various healthcare applications. Keywords: [no keywords provided]

Source:

Purdue University / 2024

Topics:

No topics listed

Co-authors:

Julia Janina Szela